The Ohio State Buckeyes and coach Ryan Day are the favorites to defend their national championship at the end of the 2025 season, having won the 12-team College Football Playoff. They have the best betting odds to win at +650, tied with Oregon and Texas. Behind them are the Georgia Bulldogs at +700, with Notre Dame standing alone at +1200. A new rivalry is brewing between the Buckeyes and the Ducks, who defeated Ohio State in the regular season but were dominated in the College Football Playoff. While they won’t face each other in the regular season, a matchup in the conference championship game is possible. In the SEC, Texas is favored to win with odds of +230, led by quarterback Arch Manning. Oregon is also a contender in the Big Ten, with close odds to win the conference. Under coach Dan Lanning, the Ducks are looking to compete for national titles, with the goal of winning the College Football Playoff. Lanning spoke about his dreams of helping his players achieve their goals and aspirations, including winning a national championship at Oregon. Heading into the 2025 season, here are the top 15 teams with the best betting odds to win the national championship.
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